Holden and Banky are comic book artists. Everything is going good for them until they meet Alyssa, also a comic book artist. Holden falls for her, but his hopes are crushed when he finds out she's a lesbian.

Although Chasing Amy's depiction of queer sexuality is frustratingly clumsy, it handles an array of thorny themes with a mixture of sensitivity, raw honesty, and writer-director Kevin Smith's signature raunchy humor.