Sir Robert Beaumont is behind schedule on a railroad in Africa. Enlisting noted engineer John Henry Patterson to right the ship, Beaumont expects results. Everything seems great until the crew discovers the mutilated corpse of the project's foreman, seemingly killed by a lion. After several more attacks, Patterson calls in famed hunter Charles Remington, who has finally met his match in the bloodthirsty lions.

The Ghost and the Darkness hits its target as a suspenseful adventure, but it falls into a trap of its own making whenever it reaches for supernatural profundity.