At the University of Chicago, a research team that includes brilliant student machinist Eddie Kasalivich experiences a breakthrough: a stable form of fusion that may lead to a waste-free energy source. However, a private company wants to exploit the technology, so Kasalivich and physicist Dr. Lily Sinclair are framed for murder, and the fusion device is stolen. On the run from the FBI, they must recover the technology and exonerate themselves.

Ironic given the scientific breakthrough at the story's core, Chain Reaction is a man-on-the-run thriller that mostly sticks to generic formula.

'Chain Reaction' delivers entertaining action sequences and strong performances, particularly from Morgan Freeman, though Keanu Reeves receives mixed reactions. However, the film disappoints as a derivative rehash of 'The Fugitive,' lacking originality and offering nothing new to the thriller genre. Weak character development, implausible plot points, and problematic writing undermine the competent direction. While some find it adequately entertaining, most consider it a forgettable, mediocre effort that fails to distinguish itself despite its talented cast and well-executed stunts.