Larry Donner, an author with a cruel ex-wife, teaches a writing workshop in which one of his students, Owen, is fed up with his domineering mother. When Owen watches a Hitchcock classic that seems to mirror his own life, he decides to put the movie's plot into action and offers to kill Larry's ex-wife, if Larry promises to murder his mom. Before Larry gets a chance to react to the plan, it seems that Owen has already set things in motion.

Danny DeVito's direction is too broad to offer the kind of nastiness that would have made Throw Momma from the Train truly special, but DeVito's on-screen chemistry with co-star Billy Crystal makes this a smoothly entertaining comedy.