Two unpopular teenagers, Gary and Wyatt, fail at all attempts to be accepted by their peers. Their desperation to be liked leads them to "create" a woman via their computer. Their living and breathing creation is a gorgeous woman, Lisa, whose purpose is to boost their confidence level by putting them into situations which require Gary and Wyatt to act like men.

Hardly in the same league as John Hughes' other teen movies, the resolutely goofy Weird Science nonetheless gets some laughs via its ridiculous premise and enjoyable performances.