Actress Myrtle Gordon is a functioning alcoholic who is a few days from the opening night of her latest play, concerning a woman distraught about aging. One night a car kills one of Myrtle's fans who is chasing her limousine in an attempt to get the star's attention. Myrtle internalizes the accident and goes on a spiritual quest, but fails to finds the answers she is after. As opening night inches closer and closer, fragile Myrtle must find a way to make the show go on.

Opening Night is as dense and difficult as one would expect from John Cassavetes, but even the director's detractors will be unable to deny the power of Gena Rowlands' performance.