The Man With No Name enters the Mexican village of San Miguel in the midst of a power struggle among the three Rojo brothers and sheriff John Baxter. When a regiment of Mexican soldiers bearing gold intended to pay for new weapons is waylaid by the Rojo brothers, the stranger inserts himself into the middle of the long-simmering battle, selling false information to both sides for his own benefit.

With Akira Kurosawa's Yojimbo as his template, Sergio Leone's A Fistful of Dollars helped define a new era for the Western and usher in its most iconic star, Clint Eastwood.